Protein Details: Acid-sensing ion channel 5

Protein ID

ICDB_Pro_1616

Protein Name

Acid-sensing ion channel 5

Gene Name

Asic5; Accn5; Blinac

Organism

Mus musculus (Mouse)

Length

495 amino acids

AlphaFoldDB

AF-Q9R0Y1-F1-model_v4.pdb

Function

Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium and lithium; and is inhibited by amiloride (By similarity).

Sequence

MEHTEKSQVHAEKGLLGKIKRYLSKRPLPSPTDRKKFDQDFAMSTSFHGIHNIAQNQNKVRKVIWLAVVLGSVSLLVWQIYSRLVNYFTWPTTTSIEVQYVEKIEFPAVTLCNLNRFQTEAVSRFGIIFFLWDIVSKVLRLQEISANNTGSPETLDFVTNHQNFSITEFVKNNGFYLNNDTLVHCEFFGKTCSPKDFKHVFTEYGNCFTFNYGENIQNKNKVSVSGRGLKLLLDVHQEEFTDNPVPGFADAGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTVHQEYPWGECNPNIKLRNFITYSTYGCLKECKARHIQRLCGCLPFLLPGNGVECDLLEYYNCVSPILDHIERKGLCTMGTHNSSCPVSCEETEYPATVSYSTFPSQRATRFLAKKLNQSQEYIRENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYFFTNFYWVLIFFLLKILETIQRTSPPQAV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Detected in cerebellum; brainstem; kidney; liver; hepatocytes; lung; intestine and embryo. In the cerebellum. restricted to interneurons in the granular layer; specifically in GRM1-expressing unipolar brush cells of the vestibulocerebellum. restricted to interneurons in the granular layer; specifically in GRM1-expressing unipolar brush cells of the vestibulocerebellum. restricted to interneurons in the granular layer; specifically in GRM1-expressing unipolar brush cells of the vestibulocerebellum.

DOI ID

10.1111/j.1469-7793.1999.0323m.x; 10.1371/journal.pone.0091326

RefSeq

NP_067345.1; XP_006501884.1; XP_006501886.1